Lactic Acidosis and exercise

[wiserd]

I'm posting here for my fiance since I'm responsible for the medical research in our relationship.

My fiance has trouble doing any extended exercise. She rapidly gets winded and feels terrible afterward. (She also sleeps for 20 hours a day at times.) I'm concerned that she has some lactic acidosis or some similar problem.

I know that the more primitive biguanadines (The class of drugs to which metformin belongs) have a tendency to produce lactic acidosis. Most stuff I've read claims that metformin does not cause this problem and attributes modern cases of lactic acidosis in PCOS to the underlying metabolic disorder which causes PCOS as opposed to the medication used to treat it.

So I have two questions;

First and formost, did anyone else have the same problem where aerobic exercise was virtually impossible for them? If so, did they find any supplement that helped them overcome the problem?

Second, I'm willing to do my own research but I wondered if there were any particularly common metabolic mutations which were known to be responsible for PCOS. I don't expect just one, since there are 100 ways to break anything complex. But PCOS does certainly seem to be a metabolic disorder (With an analogue in men) and I've gotten no information about the root cause.

Even with RT PCR (Real Time PCR) as a tool in our toolbox there doesn't seem to be much information on which mutations are typically responsible for PCOS.

My fiance is on a host of medications including T4 and T3 (though her thyroid is normal) wellbutrin and one other antidepressant I can't recall and metformin.

Thanks for any pointers and best to you all.

[arontayler]

Lactate is generally considered a major cause of fatigue during exercise and muscle soreness after exercise. However, lactate may have little effect on both. It can help to improve performance.

[karidpt]

When a part of the body is deprived of oxygen the body will break down glucose. The lactic acid is a by product of that breakdown process. There there would have to be a lot of tissue hypoxia for it to occur. Lactic acidosis is life threatening!

I haven't taken time to due indepth research, but I do remember learning in school that Metformin can cause lactic acidosis. Intense exercise can also cause it, but if she gets winded fast I don't think she could reach the levels that would be considered intense.

You are more likely to develop hyperglycemia if taking metformin with thyroid medications (such as synthroid) and birth control pills.

What type of exercise is she doing that she gets winded and feels terrible? what was the issue with the water exercise?

Has she been checked for Diabetic Ketoacidosis?

[noriorafu]

Lactic acid accumulates in muscles while relatively short, intense exercise such as swimming or running sprints. He almost immediately loses a proton captures a sodium ion or potassium and become the salt, lactate.

[mickyjulien]

Lactic acidosis is when lactic acid can be removed from the blood faster than it builds off the flow. Lactic acid is produced when oxygen levels in the body drop.It is widely believed that the lactic acidosis in fact additional proton from lactic acid production.

[deloneblack]

Each day, your body has an excess production of about 1500 mmol of lactate which enters the bloodstream and is metabolized in the liver.

[GamingGirl]

I know that I get winded quickly when exercising but it is due to me having severe Depression and Anxiety. I also would feel worse during and after I am done exercising. It felt like my whole body would be hurting while exercising and then I was achy and really tired after wards. It would not matter if it was only 2 or 3 minutes or 30 minutes.

IMHO She should see a doctor about how she is doing instead of trying to self diagnose. Its better.

[jamesyalbery]

In the power-sports such as sprinting, when energy demand is higher, faster than the ability to produce lactic acid to remove the organization and lactic acid concentration began to rise.The acidosis increases with strenuous exercise lactic acid concentration produced in a single Reaction. When ATP hydrolysis, hydrogen ions are released. ATP production of hydrogen ions is mainly responsible for lowering pH.